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To demonstrate the efficacy and safety of follitropin alfa administered with hCG on spermatogenesis in adult male hypogonadotropic hypogonadism (HH) patients.Phase III, multicenter, open-label, noncomparative.Seven US medical centers.A total of 36 adult males with severe HH.A total of 1,000 U hCG on alternate days for 3 to 6 months, with dose adjustments after 2 months, if necessary, to normalize...
Objective: To determine the prevalence and type of Yq microdeletions in 86 consecutive men that fathered 99 sons by intracytoplasmic sperm injection (ICSI) and to determine the incidence of vertical transmission and de novo deletions in these boys.Design: Prospective clinical observational study.Setting: Genetics laboratory associated with a university IVF unit.Patient(s): Eighty-six consecutive infertile...
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