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Chronic lymphocytic leukemia can evolve to an aggressive lymphoma—in most of the cases diffuse large B cells lymphoma, rarely Hodgkin lymphoma—and this complication is defined Richter syndrome (RS). Immunogenotypic features that characterize RS include unmutated IgHV status with high prevalence of IgHV4‐39/D6‐13/J5 sequence; deletion of chromosome 17p or 11q; activation of oncogenes as NOTCH1 and...
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