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The mammalian palate develops from projections of the paired maxillary processes termed palatal shelves. Shelf growth is an essential in normal palatal morphogenesis. Mesenchymal proliferation in the palatal shelves is modulated by transforming growth factor-β (TGF-β), among other growth factors. Several pathways effect TGF-β activation, including one which utilizes thrombospondin (TSP). TSP-1 is...
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