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ADP is the endogenous agonist for both P2Y 1 and P2Y 12 receptors, which are important therapeutic targets. It was previously demonstrated that ADP and a synthetic agonist, 2-methylthioadenosine 5′-diphosphate (2MeSADP), can induce apoptosis by activating the human P2Y 1 receptor heterologously expressed in astrocytoma cells. However, it was not known whether the P2Y 12...
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