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Retinoic acid (RA), the active metabolite of vitamin A, is one of the most important factors regulating spermatogenesis. RA activates downstream pathways through its receptors (retinoic acid receptor alpha [RARA], retinoic acid receptor beta, and retinoic acid receptor gamma [RARG]) and retinoid X receptors (retinoid X receptor alpha [RXRA], retinoid X receptor beta [RXRB], and retinoid X receptor...
Beta-defensins (β-defensins) are small cationic amphiphilic peptides that are widely distributed in plants, insects, and vertebrates, and are important for their antimicrobial properties. In this study, the β-defensin (Onβ-defensin) gene of the Nile tilapia (Oreochromis niloticus) was cloned from spleen tissue. Onβ-defensin has a genomic DNA sequence of 674bp and produces a cDNA of 454bp. Sequence...
In the post-genomic era, discovering relationships between genes and further constructing gene regulatory networks (GRNs) is an important problem in system biology. In case the GRNs model for a cell is known, we can simulate the gene expression to predict future states of the cell and discover new drugs based on the relationships in the GRNs. In this paper, our aim is to construct a better gene regulatory...
With the development of bioinformatics and the nearing completion of the Human Genome Project, the task of optimizing the methods of gene sequencing is becoming more and more significant. Alternative splicing, which plays an important role in regulating gene expression, widespreads in eukaryote genes. So developing a better analysis algorithm for the recognition of alternative splicing sites is a...
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