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Docosahexaenoic acid (DHA) and 3,3′,5‐triiodothyronine (T3) combined protocol affords protection against liver injury via AMPK signaling supporting energy requirements. The aim of this work was to test the hypothesis that a DHA + T3 accomplish mitochondrial adaptation through downstream upregulation of PPAR‐γ coactivator 1α (PGC‐1α). Male Sprague–Dawley rats were given daily oral doses of 300 mg DHA/kg...
Prevention of ischemia‐reperfusion liver injury is achieved by a combined omega‐3 and thyroid hormone (T3) protocol, which may involve peroxisome‐proliferator activated receptor‐α (PPAR‐α)‐fibroblast growth factor 21 (FGF21) signaling supporting energy requirements. Combined docosahexaenoic acid (DHA; daily doses of 300 mg/kg for 3 days) plus 0.05 mg T3/kg given to fed rats elicited higher hepatic...
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