Search results for: De-an Guo

Items from 1 to 20 out of 203 results

article

Dissecting chemical markers for controlling “Paozhi” method of traditional Chinese medicine with untargeted metabolomics: Vinegar‐baked Euphorbia kansui as a case study

Hui Ni, Jinjun Hou, Linlin Zhang, Xingdong Wu, more

Journal of Separation Science > 46 > 8 > n/a - n/a

The processing of Traditional Chinese Medicine requires the appropriate parameters, while the specific chemical markers are still absent to obtain the optimized processing. In this study, we used vinegar‐baked Euphorbia kansui as a case to dissect the chemical markers for the baking process using untargeted metabolomics. The robust chemical markers were selected based on the three rules, correlation,...

article

Determination of six core components from Mahuang Xuanfei Zhike syrup in rat plasma and tissues by UPLC–MS/MS: Application to a pharmacokinetics and tissue distribution study

Yang Yang, Jing Zhu, Chang‐liang Yao, De‐an Guo, more

Biomedical Chromatography > 36 > 12 > n/a - n/a

Mahuang Xuanfei Zhike (MXZ) syrup, a Chinese patent medicine, has been widely used in the clinical treatment of cough. However, there is no reported method for the quantitative analysis of the effective components of MXZ syrup in biological samples. In this study, the effective components of MXZ syrup were screened by network pharmacology and molecular docking technology. A sensitive and rapid ultra‐performance...

article

Systematical characterization and comparison of saponins in Achyranthes bidentata Blume and its three analogous species

Yingying Wang, Changliang Yao, Mengyuan Wang, Jiayuan Li, more

Phytochemical Analysis > 33 > 5 > 766 - 775

Introduction Achyranthes bidentata Blume (AB) has been used for a long time and is recorded in the Chinese Pharmacopoeia 2020 edition. It is commonly confused with Achyranthes aspera Linn (AA), Cyathula officinalis Kuan (CO) and Cyathula capitata (Wall.) Moq. (CC), belonging to the Achyranthes and Cyathula genera of the Amaranthaceae family. It is of great significance to recognize and distinguish...

article

Systematic characterization of chemical constituents in Mahuang decoction by UHPLC tandem linear ion trap‐Orbitrap mass spectrometry coupled with feature‐based molecular networking

Ling Chen, Changliang Yao, Jiayuan Li, Jing Wang, more

Journal of Separation Science > 44 > 14 > 2717 - 2727

Comprehensive characterization of traditional Chinese medicine prescriptions has long been a hurdle due to the chemical complexity and the lack of analytical tools. Mahuang decoction is a well‐known traditional Chinese medicine prescription widely used for sweating and relieving the exterior, relieving cough and asthma, but it was insufficiently chemically scrutinized. In this study, the chemical...

article

A strategy for practical authentication of medicinal plants in traditional Chinese medicine prescription, paeony root in ShaoYao‐GanCao decoction as a case study

Mengzhen Cheng, Changliang Yao, Yun Li, Zhenwei Li, more

Journal of Separation Science > 44 > 12 > 2427 - 2437

Authentication of Chinese medicine materials in prescriptions is extremely difficult due to the complicated chemical matrix. A strategy integrating in‐depth profiling, chemical marker selection, and selected detection was established and exemplarily applied to authenticate paeony root in ShaoYao‐GanCao decoction. First, an ultra‐performance liquid chromatography/linear trap quadrupole‐Orbitrap method...

article

Nontargeted metabolomic analysis and multiple criteria decision‐making method induced robust quality markers screening for the authentication of herbal medicines from different origins by taking Ophiopogon japonicus (L. f.) Ker‐Gawl. as a case study

Xu Jin, Jianqing Zhang, Yun Li, Wenyong Wu, more

Journal of Separation Science > 44 > 7 > 1440 - 1451

A key segment in medicinal plant authentication is the establishment of quality markers that embody the intrinsic metabolites difference independent of instruments and experiment conditions. A strategy integrating nontargeted metabolomics and multicriteria decision‐making model for robust quality markers discovery is presented and applied to authenticate Ophiopogon japonicus (L. f.) Ker‐Gawl. First,...

article

Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases

Alexander G. Panossian, Thomas Efferth, Alexander N. Shikov, Olga N. Pozharitskaya, more

Medicinal Research Reviews > 41 > 1 > 630 - 703

Adaptogens comprise a category of herbal medicinal and nutritional products promoting adaptability, resilience, and survival of living organisms in stress. The aim of this review was to summarize the growing knowledge about common adaptogenic plants used in various traditional medical systems (TMS) and conventional medicine and to provide a modern rationale for their use in the treatment of stress‐induced...

article

Rapid profiling of polymeric phenolic acids in Salvia miltiorrhiza by hybrid data‐dependent/targeted multistage mass spectrometry acquisition based on expected compounds prediction and fragment ion searching

Yao Shen, Zijin Feng, Min Yang, Zhe Zhou, more

Journal of Separation Science > 41 > 8 > 1888 - 1895

Phenolic acids are the major water‐soluble components in Salvia miltiorrhiza (>5%). According to previous studies, many of them contribute to the cardiovascular effects and antioxidant effects of S. miltiorrhiza. Polymeric phenolic acids can be considered as the tanshinol derived metabolites, e.g., dimmers, trimers, and tetramers. A strategy combined with tanshinol‐based expected compounds prediction,...

article

Permeability through the Caco-2 cell monolayer of 42 bioactive compounds in the TCM formula Gegen-Qinlian Decoction by liquid chromatography tandem mass spectrometry analysis

Qi Wang, Yi Kuang, Wei Song, Yi Qian, more

Journal of Pharmaceutical and Biomedical Analysis > 2017 > 146 > C > 206-213

Caco-2 cell monolayer model was used to evaluate the intestinal permeability of 42 bioactive compounds in the famous traditional Chinese medicine (TCM) formula Gegen-Qinlian Decoction (GQD). These compounds include alkaloids, flavonoids and glycosides, triterpenoid saponins, and coumarins. Their transportations across the cell monolayers in the forms of herb extract and formula extract were monitored...

article

A UPLC/MS/MS method for determination of protosappanin B in rat plasma and its application of a pharmacokinetic and bioavailability study

Wei‐Ying Chen, Xian‐Zhen Zhou, Li‐Lan Wu, Yun‐Shan Wu, more

Biomedical Chromatography > 31 > 7 > n/a - n/a

Caesalpinia sappan L. is a traditional medicinal plant which is used for promoting blood circulation and cerebral apoplexy therapy in China. Previous reports showed that the extracts of Caesalpinia sappan L. could exert vasorelaxant activity and anti‐inflammation activity. Protosappanin B is a major constituent of C. sappan L., and showed several important bioactivities. The separation was achieved...

article

Prenylated flavonoids from the stems and roots of Tripterygium wilfordii

Yang Chen, Jianping Zhao, Yixing Qiu, Hanwen Yuan, more

Fitoterapia > 2017 > 119 > C > 64-68

Phytochemical investigation on the stems and roots of Tripterygium wilfordii led to the isolation and characterization of three new prenylated flavanones, tripteryols A–C (1–3), along with (±)-5,4′-dihydroxy-2′-methoxy-6′,6″-dimethypyraro-(2″,3″:7,8)-6-methyflavanone (4), and ((2S)-5,7,4′-trihydroxy-2′-methoxy-8,5′-di(3-methyl-2-butenyl)-6-methylflavanone (5). Structures of the compounds 1–5 were...

article

A feasible, economical, and accurate analytical method for simultaneous determination of six alkaloid markers in Aconiti Lateralis Radix Praeparata from different manufacturing sources and processing ways

Yi-Bei ZHANG, Juan DA, Jing-Xian ZHANG, Shang-Rong LI, more

Chinese Journal of Natural Medicines > 2017 > 15 > 4 > 301-309

Aconiti Lateralis Radix Praeparata (Fuzi) is a commonly used traditional Chinese medicine in clinic for its potency in restoring yang and rescuing from collapse. Aconiti alkaloids, mainly including monoester-diterpenoidaconitines (MDAs) and diester-diterpenoidaconitines (DDAs), are considered to act as both bioactive and toxic constituents. In the present study, a feasible, economical, and accurate...

article

An enhanced targeted identification strategy for the selective identification of flavonoid O-glycosides from Carthamus tinctorius by integrating offline two-dimensional liquid chromatography/linear ion-trap-Orbitrap mass spectrometry, high-resolution diagnostic product ions/neutral loss filtering and liquid chromatography-solid phase extraction-nuclear magnetic resonance

Chang-liang Yao, Wen-zhi Yang, Wei Si, Yao Shen, more

Journal of Chromatography A > 2017 > 1491 > C > 87-97

Targeted identification of potentially bioactive molecules from herbal medicines is often stymied by the insufficient chromatographic separation, ubiquitous matrix interference, and pervasive isomerism. An enhanced targeted identification strategy is presented and validated by the selective identification of flavonoid O-glycosides (FOGs) from Carthamus tinctorius. It consists of four steps: (i) enhanced...

article

An in-source multiple collision-neutral loss filtering based nontargeted metabolomics approach for the comprehensive analysis of malonyl-ginsenosides from Panax ginseng, P. quinquefolius, and P. notoginseng

Xiao-jian Shi, Wen-zhi Yang, Shi Qiu, Chang-liang Yao, more

Analytica Chimica Acta > 2017 > 952 > C > 59-70

The simultaneous identification and quantification of target metabolites from herbal medicines are difficult to implement by the full-scan MS based nontargeted metabolomics approaches. Here an in-source multiple collision-neutral loss filtering (IMC-NLF) based nontargeted metabolomics approach is developed and applied to identify and quantify the variations of malonyl-ginsenosides, a common group...

article

New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation

Hui-qin Pan, Wen-zhi Yang, Dan Zhao, Cheng Luo, more

Fitoterapia > 2017 > 116 > C > 85-92

Four new alkaloids, comprising three 3-oxo-3,7-seco-oxindole alkaloids (hirsutanine D–F, 1–3) and one oxindole alkaloid N-oxide (uncarine B N-oxide, 4), together with four known heteroyohimbine-type oxindole alkaloids, were isolated from the stems of Uncaria hirsuta Havil. Structures of 1–4 were elucidated by extensive NMR and HR-ESIMS data analyses. Compound 3 is the first 3-oxo-3,7-seco-oxindole...

article

A Strategy Combining Higher Energy C-Trap Dissociation with Neutral Loss- and Product Ion-Based MSⁿ Acquisition for Global Profiling and Structure Annotation of Fatty Acids Conjugates

Qi-rui Bi, Jin-jun Hou, Min Yang, Yao Shen, more

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 3 > 443-451

Fatty acids conjugates (FACs) are ubiquitous but found in trace amounts in the natural world. They are composed of multiple unknown substructures and side chains. Thus, FACs are difficult to be analyzed by traditional mass spectrometric methods. In this study, an integrated strategy was developed to global profiling and targeted structure annotation of FACs in complex matrix by LTQ Orbitrap. Dicarboxylic...

article

Amelioration of salvianolic acid C on aortic structure in apolipoprotein E-deficient mice treated with angiotension II

Peng Wu, Na Han, Haitao Yu, Linlin Wang, more

Life Sciences > 2016 > 166 > C > 75-81

Aortic aneurysm is a disastrous vascular disease with high morbidity and mortality. Matrix metalloproteinases (MMPs), especially MMP-9, is implicated in the development of aortic aneurysm, but the effective MMP inhibitors are far from development. To develop new candidate compound for aortic aneurysm therapy, we evaluated the effects of salvianolic acid C (SalC) against the formation of aortic aneurysm...

article

Development of specific and quantitative methods for the quality control of the polysaccharides from sea-tangle and sargassum

Hua-Li LONG, Jing-Xian ZHANG, Ji-Ling GUO, Guo-Qi SUI, more

Chinese Journal of Natural Medicines > 2016 > 14 > 12 > 954-960

Polysaccharides from numerous traditional Chinese medicines have been proven as the bioactive ingredients and are hence used as the quality control markers. However, the assessment criteria always show a poor specificity, due to the lack of systematic comparison among the analogous herbs. In the present study, two similar materials, namely sea-tangle and sargassum, were selected as the model herbs...

article

Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress

Li-Xing FENG, Peng SUN, Tian MI, Miao LIU, more

Chinese Journal of Natural Medicines > 2016 > 14 > 11 > 856-864

Arisaema heterophyllum Blume is one of the three medicinal plants known as traditional Chinese medicine Rhizoma Arisaematis (RA). RA has been popularly used to treat patients with convulsions, inflammation, and cancer for a long time. However, the underlying mechanisms for RA effects are still unclear. The present study was designed to determine the cytotoxicity of agglutinin isolated from Arisema...

article

Identification and differentiation of Panax ginseng, Panax quinquefolium, and Panax notoginseng by monitoring multiple diagnostic chemical markers

Wenzhi Yang, Xue Qiao, Kai Li, Jingran Fan, more

Acta Pharmaceutica Sinica B > 2016 > 6 > 6 > 568-575

To differentiate traditional Chinese medicines (TCM) derived from congeneric species in TCM compound preparations is usually challenging. The roots of Panax ginseng (PG), Panax quinquefolium (PQ) and Panax notoginseng (PN) are used as popular TCM. They contain similar triterpenoid saponins (ginsenosides) as the major bioactive constituents. Thus far, only a few chemical markers have been discovered...

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QUALITY CONTROL (13)
BIOTRANSFORMATION (10)
FLAVONOIDS (10)
GANODERMA LUCIDUM (10)
TRADITIONAL CHINESE MEDICINE (9)
CYTOTOXICITY (7)
SALVIA MILTIORRHIZA (7)
LC/MS/MS (6)
METABOLITES IDENTIFICATION (6)
PANAX NOTOGINSENG (6)
PHARMACOKINETICS (6)
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SALVIANOLIC ACID B (5)
TRITERPENOID (5)
TRITERPENOIDS (5)
CHINESE HERBAL MEDICINE (4)
COLUMN LIQUID CHROMATOGRAPHY (4)
GLYCYRRHIZA URALENSIS (4)
HPLC (4)
LICORICE (4)
METABOLISM (4)
PHENOLIC COMPOUNDS (4)
SALVIANOLIC ACIDS (4)
BUFADIENOLIDES (3)
BUFALIN (3)
DETERMINATION (3)
FLAVONOID (3)
GEGEN-QINLIAN DECOCTION (3)
GINSENOSIDE (3)
HPLC-DAD (3)
LC/MS (3)
PANAX GINSENG (3)
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CORTEX LYCII (2)
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INFONA - science communication portal

Search results for: De-an Guo

Dissecting chemical markers for controlling “Paozhi” method of traditional Chinese medicine with untargeted metabolomics: Vinegar‐baked Euphorbia kansui as a case study

Determination of six core components from Mahuang Xuanfei Zhike syrup in rat plasma and tissues by UPLC–MS/MS: Application to a pharmacokinetics and tissue distribution study

Systematical characterization and comparison of saponins in Achyranthes bidentata Blume and its three analogous species

Systematic characterization of chemical constituents in Mahuang decoction by UHPLC tandem linear ion trap‐Orbitrap mass spectrometry coupled with feature‐based molecular networking

A strategy for practical authentication of medicinal plants in traditional Chinese medicine prescription, paeony root in ShaoYao‐GanCao decoction as a case study

Nontargeted metabolomic analysis and multiple criteria decision‐making method induced robust quality markers screening for the authentication of herbal medicines from different origins by taking Ophiopogon japonicus (L. f.) Ker‐Gawl. as a case study

Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases

Rapid profiling of polymeric phenolic acids in Salvia miltiorrhiza by hybrid data‐dependent/targeted multistage mass spectrometry acquisition based on expected compounds prediction and fragment ion searching

Permeability through the Caco-2 cell monolayer of 42 bioactive compounds in the TCM formula Gegen-Qinlian Decoction by liquid chromatography tandem mass spectrometry analysis

A UPLC/MS/MS method for determination of protosappanin B in rat plasma and its application of a pharmacokinetic and bioavailability study

Prenylated flavonoids from the stems and roots of Tripterygium wilfordii

A feasible, economical, and accurate analytical method for simultaneous determination of six alkaloid markers in Aconiti Lateralis Radix Praeparata from different manufacturing sources and processing ways

An in-source multiple collision-neutral loss filtering based nontargeted metabolomics approach for the comprehensive analysis of malonyl-ginsenosides from Panax ginseng, P. quinquefolius, and P. notoginseng

New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation

A Strategy Combining Higher Energy C-Trap Dissociation with Neutral Loss- and Product Ion-Based MSⁿ Acquisition for Global Profiling and Structure Annotation of Fatty Acids Conjugates

Amelioration of salvianolic acid C on aortic structure in apolipoprotein E-deficient mice treated with angiotension II

Development of specific and quantitative methods for the quality control of the polysaccharides from sea-tangle and sargassum

Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress

Identification and differentiation of Panax ginseng, Panax quinquefolium, and Panax notoginseng by monitoring multiple diagnostic chemical markers

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