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Objective. This study was conducted to examine differences in flurbiprofen metabolism among individuals with the CYP2C9*1/*1, *1/*2, and *1/*3 genotypes. Methods. Fifteen individuals with the CYP2C9*1/*1 (n=5), *1/*2 (n=5), and *1/*3 (n=5) genotypes received a single 50-mg oral dose of flurbiprofen. Plasma and urine samples were collected over 24h, and flurbiprofen and 4-hydroxyflurbiprofen pharmacokinetic...
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