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Obesity is primarily caused by the excessive accumulation of white adipose tissues (WAT). We previously obtained an adipocyte-specific aptamer termed Adipo8 in vitro. In this present study, this adipocyte-specific aptamer Adipo8 was first chemically modified by introduction of phosphorothioate linkages (PS-linkages) and then conjugated to polyethylene glycol (PEG), we tested whether this modified...
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