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Disaggregation‐activated turn‐on imaging probes were designed using BODIPY fluorophore and the pan‐COX inhibitor indomethacin, as reported by Woo Young Jang, Jun‐Seok Lee et al. in their Communication (e202405525). The aggregation‐state‐dependent imaging probe demonstrated its practical usages for pan‐COX imaging of fixed clinical tissue from human sarcoma. The cover image was created with BioRender...
Eine lebende Zelle besteht aus hochgeordneten Strukturen, bei denen die Lokalisierung niedermolekularer Verbindungen durch chemische Eigenschaften festgelegt wird. Wegen dieser intrazellulären Barrieren kann die Bindung von Bindeproteinen, die bei In‐vitro‐Experimenten identifiziert wurden, in lebenden Zellen weniger effektiv sein. In der Zuschrift auf S. 2813 ff. beschreiben Y. T. Chang et al. ein...
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