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Fibroblast growth factor 1 (FGF1) is a heparin-binding proangiogenic protein. FGF1 lacks the conventional N-terminal signal peptide required for secretion through the endoplasmic reticulum (ER)–Golgi secretory pathway. FGF1 is released through a Cu 2+ -mediated nonclassical secretion pathway. The secretion of FGF1 involves the formation of a Cu 2+ -mediated multiprotein release complex...
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