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Objective Cathepsin L (CL) is potentially involved in joint destruction and in antigen presentation in rheumatoid arthritis. In order to define the roles of this protease in arthritis development we analysed the antigen-induced arthritis (AIA) in CL-deficient (CL−/−) mice. Methods Antigen-induced arthritis was induced in CL−/− and wild-type mice. Complete CL deficiency resulted in an impaired positive...
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