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Bovine parathyroid cells were used to study parathyroid hormone (PTH) release and the cytoplasmic Ca 2+ concentration (Ca 2+1 ). When the extracellular Ca 2+ concentration was decreased from 3.0 to 0.5 mM, perifused cells reacted with rapid stimulation of PTH release. However, a further reductionof extracellular Ca 2+ to < 10 nM resulted...
The Ca 2+ receptor mechanism of the parathyroid cell was studied using La 3+ as a probe. La 3+ was found to bind to the cell surface without further penetration. Measurements of 45 Ca fluxes and the cytoplasmic Ca 2+ concentration (Ca i2+ ) revealed a stimulatory component in the action of La 3+ on Ca ...
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