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High coverage whole genome DNA-sequencing enables identification of somatic structural variation (SSV) more evident in paired tumor and normal samples. Recent studies show that simultaneous analysis of paired samples provides a better resolution of SSV detection than subtracting shared SVs. However, available tools can neither identify all types of SSVs nor provide any rank information regarding their...
ChlP-chip experiments are performed to determine binding sites for transcription factors (TFs). Conventional TF-gene regulation is generated based on p-value cutoff of the binding sites as well as their distance to nearest genes. Taking into account that binding sites of one ChlP-chip experiment should follow the same specific location distribution, we proposed a statistical model using both location...
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