Search results for: Seppo Kähkönen

Items from 1 to 20 out of 39 results

article

Biperiden selectively induces memory impairment in healthy volunteers: no interaction with citalopram

Anke Sambeth, Wim J. Riedel, Inge Klinkenberg, Seppo Kähkönen, more

Psychopharmacology > 2015 > 232 > 11 > 1887-1897

Rationale Traditionally, the non-selective muscarinic antagonist scopolamine has been used to induce episodic memory impairments as found in Alzheimer’s disease (AD). However, it also impairs attention and induces drowsiness. Muscarinic antagonists more selective for the M1 receptor might, therefore, be preferred. Objectives We examined the effects of the M1 antagonist biperiden on cognitive functions...

article

Author's response

Marcelo Chiramberro, Björn Appelberg, Nina Lindberg, Seppo Kähkönen, more

Brain Stimulation > 2014 > 7 > 2 > 338

article

The neural basis of sublexical speech and corresponding nonspeech processing: A combined EEG–MEG study

Soila Kuuluvainen, Päivi Nevalainen, Alexander Sorokin, Maria Mittag, more

Brain and Language > 2014 > 130 > Complete > 19-32

We addressed the neural organization of speech versus nonspeech sound processing by investigating preattentive cortical auditory processing of changes in five features of a consonant–vowel syllable (consonant, vowel, sound duration, frequency, and intensity) and their acoustically matched nonspeech counterparts in a simultaneous EEG–MEG recording of mismatch negativity (MMN/MMNm). Overall, speech–sound...

article

Postural control in restless legs syndrome with medication intervention using pramipexole

Aulikki Ahlgrén-Rimpiläinen, Hannu Lauerma, Seppo Kähkönen, Heikki Aalto, more

Neurological Sciences > 2014 > 35 > 2 > 199-204

Central dopamine regulation is involved in postural control and in the pathophysiology of restless legs syndrome (RLS) and Parkinson’s disease (PD). Postural control abnormalities have been detected in PD, but there are no earlier studies with regard to RLS and postural control. Computerized force platform posturography was applied to measure the shift and the velocity (CPFV) of center point of forces...

article

Repetitive Transcranial Magnetic Stimulation Induced Seizures in an Adolescent Patient with Major Depression: A Case Report

Marcelo Chiramberro, Nina Lindberg, Erkki Isometsä, Seppo Kähkönen, more

Brain Stimulation > 2013 > 6 > 5 > 830-831

article

Validation of head movement correction and spatiotemporal signal space separation in magnetoencephalography

Jukka Nenonen, Jussi Nurminen, Dubravko Kičić, Rozaliya Bikmullina, more

Clinical Neurophysiology > 2012 > 123 > 11 > 2180-2191

Our aim was to assess the effectiveness and reliability of spatiotemporal signal space separation (tSSS) and movement correction (MC) in magnetoencephalography (MEG) recordings disturbed by head movements and magnetized material on the head.We recorded MEG from 20 healthy adults in stationary (reference) head position and during controlled head movements. Nearby magnetic interference sources were...

article

Effects of alcohol withdrawal on cardiovascular system

Seppo Kähkönen, Edwin Zvartau, Jari Lipsanen, Boris Bondarenko

Progress in Neuropsychopharmacology & Biological Psychiatry > 2011 > 35 > 2 > 550-553

Alcohol withdrawal syndrome (AWS) develops after cessation of alcohol intake in alcoholic patients characterizing psychiatric symptoms and changes in autonomous nervous systems. We studied cardiovascular changes during different phases of AWS (1, 2, 3 and 10days after admission for detoxification; n=34) and compared them with those in early recovery (at least 1month of abstinence; n=30). The results...

article

Consensus paper: Combining transcranial stimulation with neuroimaging

Hartwig R. Siebner, Til O. Bergmann, Sven Bestmann, Marcello Massimini, more

Brain Stimulation > 2009 > 2 > 2 > 58-80

In the last decade, combined transcranial magnetic stimulation (TMS)-neuroimaging studies have greatly stimulated research in the field of TMS and neuroimaging. Here, we review how TMS can be combined with various neuroimaging techniques to investigate human brain function. When applied during neuroimaging (online approach), TMS can be used to test how focal cortex stimulation acutely modifies the...

article

Modulation of somatosensory evoked fields from SI and SII by acute GABAA-agonism and paired-pulse stimulation

Juha Huttunen, Eero Pekkonen, Reetta Kivisaari, Taina Autti, more

NeuroImage > 2008 > 40 > 2 > 427-434

The purpose of the present study was to shed light on the physiology underlying somatosensory evoked magnetic fields (SEFs) by means of pharmacological manipulation with the GABA_A agonist lorazepam and paired-pulse stimulation. SEFs were recorded from the primary (SI) and secondary (SII) somatosensory cortices following median nerve stimulation. Responses were obtained to single stimuli every 2 s...

article

The effect of methylphenidate on auditory information processing in healthy volunteers: a combined EEG/MEG study

Milena Korostenskaja, Dubravko Kičić, Seppo Kähkönen

Psychopharmacology > 2008 > 197 > 3 > 475-486

Introduction The psychomotor stimulant methylphenidate (MPH) has been shown to improve attentional processes, reflected in behavioural measures such as vigilance, reaction time and visual attention tasks. The neural mechanisms of MPH action on sensory information processing, however, remain poorly understood. To the authors’ knowledge, this present study is the first to investigate whether a single...

article

Cardiovascular effects of propranolol in patients with alcohol dependence during withdrawal

Seppo Kähkönen, Boris Bondarenko, Jari Lipsanen, Edwin Zvartau

International Journal of Psychophysiology > 2007 > 66 > 3 > 225-230

The cardiovascular effects of the β-adrenergic receptor antagonist propranolol (40 mg) were compared in 20 alcohol-dependent subjects during alcohol withdrawal syndrome (WS; n=10) on days 1, 2, 3, and 10 to those during remission (n=10; 50±7.7 days). Significant differences were observed in negative chronotropic and hypotensive effects during withdrawal compared to remission. The initial level of...

article

Effects of alcohol on TMS-evoked N100 responses

Seppo Kähkönen, Juha Wilenius

Journal of Neuroscience Methods > 2007 > 166 > 1 > 104-108

TMS combined with simultaneous EEG is a novel brain imaging tool allowing investigation local excitability of human cortex. As alcohol acts through increasing function of A-type γ-aminobutyric acid receptors and attenuating the function of glutaminergic NMDA-receptors-related excitation, we tested whether TMS-evoked N100 response which is thought to reflect cortical inhibitory processes, might be...

article

Impaired pre-attentive auditory processing in opioid dependence with and without benzodiazepine co-dependence revealed by combined magnetoencephalography and electroencephalography

Reetta Kivisaari, Reia Lehtinen, Taina Autti, Varpu Puuskari, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 2007 > 31 > 7 > 1378-1386

Cognitive dysfunctions may be a significant factor in drug-seeking behavior, reducing the efficiency of rehabilitation in opioid dependence. Neurophysiological basis of these dysfunctions is poorly understood. 21 opioid-dependent patients and 15 healthy controls with no experience of illicit drugs were studied with simultaneous electroencephalography (EEG) and magnetoencephalography (MEG). Among opioid...

article

Artifact correction and source analysis of early electroencephalographic responses evoked by transcranial magnetic stimulation over primary motor cortex

Vladimir Litvak, Soile Komssi, Michael Scherg, Karsten Hoechstetter, more

NeuroImage > 2007 > 37 > 1 > 56-70

Analyzing the brain responses to transcranial magnetic stimulation (TMS) using electroencephalography (EEG) is a promising method for the assessment of functional cortical connectivity and excitability of areas accessible to this stimulation. However, until now it has been difficult to analyze the EEG responses during the several tens of milliseconds immediately following the stimulus due to TMS-induced...

article

Effects of NMDA receptor antagonist memantine on mismatch negativity

Milena Korostenskaja, Vadim V. Nikulin, Dubravko Kičić, Anna V. Nikulina, more

Brain Research Bulletin > 2007 > 72 > 4-6 > 275-283

Mismatch negativity (MMN) and its magnetic counterpart (MMNm) have been shown to be altered in patients with various psychiatric and neurological disorders, e.g. Alzheimer's disease and schizophrenia, indicating deficits in involuntary attention. N-Methyl-d-aspartate (NMDA) receptor-mediated glutamate dysfunction is suggested to underlie these deficits. However, the role of NMDA receptors in involuntary...

article

Opioid withdrawal results in an increased local and remote functional connectivity at EEG alpha and beta frequency bands

Andrew A. Fingelkurts, Alexander A. Fingelkurts, Reetta Kivisaari, Taina Autti, more

Neuroscience Research > 2007 > 58 > 1 > 40-49

Withdrawal may be a natural model to study craving and compulsive drug seeking, since craving can be viewed as a conditioned dysphoric state. It has been suggested that functional connectivity between brain areas may be of major value in explaining excessive craving and compulsive drug seeking by providing essential link between psychological and biological processes. Considering that withdrawal initiates...

article

Composition of EEG oscillations and their temporal characteristics: Methadone treatment

Alexander A. Fingelkurts, Seppo Kähkönen, Andrew A. Fingelkurts, Reetta Kivisaari, more

International Journal of Psychophysiology > 2007 > 64 > 2 > 130-140

In this study, we examine the composition of electroencephalographic (EEG) oscillations within a broad frequency band (0.5–30 Hz) for opioid abuse (22 patients), during withdrawal (13 patients), and after 6 months of methadone treatment (6 patients) and in 14 healthy subjects during a resting condition (closed eyes). The exact compositions of EEG oscillations and their temporal behaviour were assessed...

article

Nitric oxide mediates cardiovascular symptoms in alcohol withdrawal

Seppo Kähkönen, Bondarenko Boris, Zvartau Edwin

Progress in Neuropsychopharmacology & Biological Psychiatry > 2007 > 31 > 3 > 761-765

We studied whether nitric oxide is involved in cardiovascular symptoms in alcohol withdrawal. Cardiovascular effects of isosorbide dinitrate (ISDN; 20 mg sublingually), a nitric oxide donor were compared in 21 alcohol-dependent subjects during alcohol withdrawal (n=11) on days 1, 2, 3, and 10 to those during remission (n=10; duration=60.7±10.5 days). Cardiovascular parameters were measured non-invasively...

article

MRI-constrained spectral imaging of benzodiazepine modulation of spontaneous neuromagnetic activity in human cortex

Jyrki Ahveninen, Fa-Hsuan Lin, Reetta Kivisaari, Taina Autti, more

NeuroImage > 2007 > 35 > 2 > 577-582

Spontaneous electromagnetic brain rhythms have been widely used in human neuropharmacology, but their applicability is complicated by the difficulties to localize their origins in the human cortex. Here, we used a novel multi-modal non-invasive imaging approach to localize lorazepam (30 μg/kg i.v.) modulation of cortical generators of spontaneous brain rhythms. Eight healthy subjects were measured...

article

Reorganization of the composition of brain oscillations and their temporal characteristics in opioid dependent patients

Alexander A. Fingelkurts, Andrew A. Fingelkurts, Reetta Kivisaari, Taina Autti, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 2006 > 30 > 8 > 1453-1465

In the present study, we examined the composition of electroencephalographic (EEG) brain oscillations in broad frequency band (0.5–30 Hz) in 22 opioid-dependent patients and 14 healthy subjects during resting condition (closed eyes). The exact compositions of brain oscillations and their temporal behavior were assessed by the probability–classification analysis of short-term EEG spectral patterns...

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Search results for: Seppo Kähkönen

Biperiden selectively induces memory impairment in healthy volunteers: no interaction with citalopram

Author's response

The neural basis of sublexical speech and corresponding nonspeech processing: A combined EEG–MEG study

Postural control in restless legs syndrome with medication intervention using pramipexole

Repetitive Transcranial Magnetic Stimulation Induced Seizures in an Adolescent Patient with Major Depression: A Case Report

Validation of head movement correction and spatiotemporal signal space separation in magnetoencephalography

Effects of alcohol withdrawal on cardiovascular system

Consensus paper: Combining transcranial stimulation with neuroimaging

Modulation of somatosensory evoked fields from SI and SII by acute GABAA-agonism and paired-pulse stimulation

The effect of methylphenidate on auditory information processing in healthy volunteers: a combined EEG/MEG study

Cardiovascular effects of propranolol in patients with alcohol dependence during withdrawal

Effects of alcohol on TMS-evoked N100 responses

Impaired pre-attentive auditory processing in opioid dependence with and without benzodiazepine co-dependence revealed by combined magnetoencephalography and electroencephalography

Artifact correction and source analysis of early electroencephalographic responses evoked by transcranial magnetic stimulation over primary motor cortex

Effects of NMDA receptor antagonist memantine on mismatch negativity

Opioid withdrawal results in an increased local and remote functional connectivity at EEG alpha and beta frequency bands

Composition of EEG oscillations and their temporal characteristics: Methadone treatment

Nitric oxide mediates cardiovascular symptoms in alcohol withdrawal

MRI-constrained spectral imaging of benzodiazepine modulation of spontaneous neuromagnetic activity in human cortex

Reorganization of the composition of brain oscillations and their temporal characteristics in opioid dependent patients

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