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Background Imatinib causes increased turnover of stromal collagen, reduces collagen fibril diameter, enhances extracellular fluid turnover and lowers interstitial fluid pressure (IFP) in the human colonic carcinoma KAT-4/HT-29 (KAT-4) xenograft model. Methods We compared the effects of imatinib on oxygen levels, vascular morphology and IFP in three experimental tumor models differing in their content...
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