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Phosphorylation of surface-exposed tyrosine residues negatively impacts the transduction efficiency of recombinant AAV2 vectors. Pre-treatment of cells with specific cellular serine/threonine kinase inhibitors also significantly increased the transduction efficiency of AAV2 vectors. We reasoned that site-directed mutagenesis of surface-exposed serine residues might allow the vectors to evade phosphorylation...
Biclustering the gene expressing data is an important task in bioinformatics. A parallel biclustering algorithm for gene expressing data is presented. The algorithm starts from the data sets containing pair of rows and columns of the data matrix, and gets the biclusters by gradually adding columns and rows on the data sets. A pruning technique is also proposed to reduce computing time. Experimental...
A biclustering algorithm for gene expressing data is presented. Based on the anti-monotones property of the quality of the data sets with their sizes, the algorithm can get the final biclusters by gradually adding columns and rows on the data sets. Experimental results show that our algorithm has higher processing speed and quality of clustering than other similar algorithms.
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