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Pearl gentian grouper, Epinephelus lanceolatus × Epinephelus fuscoguttatus, is a hybrid species with increasing market requirement in China. A disease outbreak occurred in the fish juvenile stages in Shandong Province, P.R. China. The gross signs were characterized by mass mortality, exhibiting dark skin coloration, reduce of feeding and having abnormal swimming behavior. Based on histopathological...
In this paper, a newly algorithm is proposed to deal with the Gap detection and duplicate removal problems in protein sequence alignment. After analysed the different causes of Gaps from the view of different points of mutations, there are two types of Gaps should be treated using different algorithms. The duplicate removal algorithms attempt to find all the duplicate Gaps is described with the feature...
In vivo, cardiomyocytes are stimulated by electricity continuously. So electrical stimulation is an indispensable factor for cardiomyocytes cultured in vitro. In this study, the experimental group neonatal cardiomyocytes received electrical stimulation at different intensities and different frequencies by a electrical stimulation device in vitro. After stimulation, The morphology and beating of cardiomyocytes...
Mechanical stimulations are critical factors in regulation activities of cardiomyocytes in vivo and in vitro. Cyclic mechanical stretch is an indispensable factor for cardiomyocytes cultured in vitro and construction of engineered cardiac tissue. Optimized parameter of cyclic stretch is key factor for cardiomyocytes culture in vitro. In this study, neonatal cardiomyocytes were subjected to cyclic...
Molecular docking is one of the most important methods in computer assisted drug design, with the dreg activity of flexible ligands verified during docking to macromolecular targets, its use value could be determined. Because of the large quantity of ligands in data bank, it will be extraordinarily time-consuming to compute the interaction between ligands and macromolecules. The paper lays emphasis...
Identifying binding motifs or critical sequence segments is a key step toward understanding the mechanism of interactions between hepatitis C virus (HCV) and host cell proteins, such as human proteins. In the present study, we found a pair of binding motifs, G185-L234 in HCV NS5A proteins and L-X(3,5)-E-[AEGNQST] in human proteins, which are considered to be a key determinant for the interactions...
In contrast to the abundant data on hepatitis C virus (HCV) and human protein sequences, little is known about the interactions between HCV and human proteins. Hence, discovering binding domain pairs or inter-domain paths at the residue level is of general importance in the study of the interactions between HCV and human proteins. In this study, we analyzed all known binding domain pairs of HCV proteins...
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