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Solid tumor hypoxia is a poor outcome predictor for radiotherapy, chemotherapy and also surgical treatment options. Recently, oxygen microbubbles (OMB) have shown promise as an adjuvant therapy to relieve such tumor hypoxia. However, a key limiting factor remains the lack of available data in vivo of the dose-response and time-dynamics of this OMB-induced reoxygenation. Here we study the kinetics...
It is well-established that tumor hypoxia negatively impacts treatment outcome for radiation therapy (RT). In particular, tumor cell resistance to radiotherapy is increased 3-fold under anoxic conditions. Hypoxia hinders direct “oxygen radiosensitization” (increased free radical oxidative damage and formation of difficult-to-repair organic peroxides during RT), but also promotes radioresistance through...
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