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Songorine, a diterpenoid alkaloid isolated from the genus Aconitum, was recently found to enhance the excitatory synaptic transmission in rat hippocampus. The mechanism underlying the effects was examined in the present study. The alkaloid at 0.1-300 μM inhibited the specific binding of [ 3 H]muscimol to Triton-treated synaptic membranes of rat brain in a concentration-dependent manner (IC...
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