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Sorafenib is an effective palliative treatment against hepatocellular carcinoma (HCC), however the oral tablet formulation is associated with severe side effects and low serum levels suggest delivery of insufficient doses. A drug-eluting bead formulation for catheter-directed delivery should increase tumor doses and decrease side effects. Thus, polylactide-co-glycolide (PLG) microspheres were developed...
To assess the efficacy and safety of transarterial chemoembolization (TACE) combined with sorafenib for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT).106 patients with advanced HCC were enrolled in this study. Among them, 45 were treated with TACE and sorafenib (T+S group), 61 were treated with TACE alone (T group). In T+S group, sorafenib was orally administered 3-5...
In pre-clinical studies, super-paramagnetic iron oxide nanoparticles (SPIOs) have shown promise as drug delivery vehicles for hepatocellular carcinoma (HCC). A major limitation of conventional intravenous (IV) administration of SPIOs is deposition in the reticuloendothelial system instead of the target tumor. Local image-guided delivery might be one approach to overcome this limitation and potentially...
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