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X-ray repair cross-complementing 1 (XRCC1) plays a critical role in base excision repair and genetic variations of XRCC1 may be associated with cancer susceptibility. We tested this hypothesis by examining the contribution of polymorphism in the regulatory region of XRCC1 −77T>C to risk of breast cancer in 995 patients and 1,004 controls. We found this polymorphism was associated with an increased...
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