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Anti‐angiogenesis has been a promising strategy for cancer therapy. However, many signal pathways are activated during anti‐angiogenic treatment to counteract the therapeutic efficacy. Among these pathways, evidence has directly pointed to the phosphatidylinositol 3‐kinase/Akt (PI3K/Akt) pathway, whose activation resulted in tolerance to the absence of nutrients and oxygen when tumor angiogenesis...
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