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The biocidal agent tributyltin (TBT) is used mainly in wood preservation and marine antifouling paints. Occupational exposure of workers to TBT can result in skin and eye irritation, and severe dermatitis has been reported after direct contact with the skin. We have previously demonstrated that TBT induced both intracellular production of IL-1α and its release into culture medium in a murine keratinocyte...
We investigated whether the pesticide triphenyl tin chloride (TPT) causes apoptosis in HL-60 promyelocytic cells and, if so, by what mechanisms. We report that 5 μM TPT increased intracellular Ca 2+ in HL-60 cells within seconds; concomitantly actin depolymerization was detected 30 sec and 1 min after the treatment. This was followed 15 min later by an increase in the intracellular...
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