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Thalidomide has been shown to reduce the production of tumor necrosis factor-α (TNF-α), a cytokine with deleterious pathophysiologic effects in various diseases. In search of thalidomide analogues with improved TNF-α inhibiting properties, 5-ethyl-1-phenyl-5-(3,4,5,6-tetrafluorophthalimido)barbituric acid (TFBA) was found to be superior to thalidomide. Besides TNF-α, TFBA also suppressed interleukin-6...
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