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We tested the influence of IFNγ on proteasome activity in parental Hep G2 cells that do not metabolize ethanol, as well as in recombinant Hep G2-derived cells that express either or both alcohol dehydrogenase (ADH) and cytochrome P4502E1 (CYP2E1). IFNγ treatment increased proteasome activity in VL-17A (ADH + , CYP2E1 + ) and E-47 (CYP2E1 + ) cells, but not in Hep G2, VI-R2...
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