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Enterovirus D68 (EV-D68) is a member of the Picornaviridae family. Although EV-D68-associated infection was once considered rare, it has been increasing in recent years. EV-D68 infection is most frequently associated with respiratory illness. However, it has also been implicated in a polio-like neurological disorder, acute flaccid myelitis. Although sialic acid has been implicated in EV-D68 entry,...
The deoxynucleoside triphosphate triphosphohydrolase SAMHD1 is a myeloid cell-specific retroviral restriction factor that can be inactivated by viral protein Vpx from HIV-2 and certain SIV. In this issue of Cell Host & Microbe, Kyei et al. (2015) report that cyclin L2 enhances HIV-1 infection in macrophages by regulating SAMHD1.
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