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AKR1B10, a human member of the aldo-keto reductase (AKR) superfamily, was recently identified to be linked with several types of cancers, while exhibiting high sequence identity with human aldose reductase (AKR1B1). In order to identify potential inhibitors of AKR1B10, the NCI database which contains approximately 250,000 chemical structures was screened using in silico techniques. Computer aided...
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