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The effects of transforming growth factor-α (TGF-α) on cell growth were studied in human glioma U251 cells transfected with antisense TGF-α vectors (pcDNAI.neo). Several antisense clones showed a marked decrease in growth rate in serum-free medium but not in medium containing 10% FBS, compared with those of parental cells and clones from sense or vector transfectants. Antisense clones also produced...
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