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We have previously evaluated the measurement of viability and cytokine release from skin equivalents, for predicting the skin irritation potential of topically applied surfactants and demonstrated that IL-1α and interleukin-1 receptor antagonist (IL-1ra) release from epidermal skin equivalents correlates with skin irritation potential. In this study, the utility of the model was confirmed by the evaluation...
A number of diverse in vitro model systems have been employed for the prediction of irritation potential of test articles. Monolayer systems have proven to be useful for preliminary screening but are not always capable of distinguishing mild effects or adaptable to fully formulated product. Three-dimensional reconstructed skin equivalents integrate cellular toxicity with the kinetics of exposure and...
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