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We present here the 9-step synthesis of 10, the first rhenium organometallic complex of oestradiol substituted at the 11ß position. This hormone retains acceptable binding affinity for the oestradiol receptor at 0 °C (11 %) while its partition coefficient shows it is more lipophilic than oestradiol. The test of its agonist/antagonist activity on oestrogen receptor positive cell line (MVLN) shows it...
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