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The identification of different mechanisms by which tumours escape from the immune system have helped to judge the clinical relevance of several phenotypic changes that occur during tumour development. As discussed at a recent meeting, changes in HLA class I expression play a leading role in the tumour-host scenario.
HLA class I downregulation is a frequent event associated with tumour invasion and development. Altered HLA class I tumour phenotypes can have profound effects on T-cell and natural killer (NK)-cell antitumour responses. Here, Federico Garrido and colleagues analyse these altered tumour phenotypes in detail, indicating their potential relevance for implementation of immunotherapeutic protocols and...
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