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An impediment to progress in mood disorders research is the lack of analytically valid and qualified diagnostic and treatment biomarkers. Consistent with the National Institute of Mental Health (NIMH)'s Research Domain Criteria (RDoC) initiative, the lack of diagnostic biomarkers has precluded us from moving away from a purely subjective (symptom‐based) toward a more objective diagnostic system. In...
A better understanding of the neurobiology of mood disorders, informed by preclinical research and bi‐directionally translated to clinical research, is critical for the future development of new and effective treatments. Recently, diverse new targets/compounds have been specifically tested in preclinical models and in proof‐of‐concept studies, with potential relevance as treatments for mood disorders...
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