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Image-guided sonothrombolysis was prototyped on a modified ultrasound imaging system iE33 and further evaluated using a porcine acute ischemic stroke model. After 20 to 40 minute sonothrombolysis treatment with systemic infusion of Definity microbubbles, contrast reperfusion and arterial recanalization were observed on low MI ultrasound contrast imaging and X-ray based angiography, respectively. The...
Ultrasound and intravenous microbubbles have been used in recanalizing intravascular thrombi which cause ischemic stroke, myocardial infarction, and other vascular thrombo-embolic events. In previous studies, inertial cavitation (IC) produced by high mechanical index (MI) ultrasound has been shown to be effective in dissolving acute thrombi. However, IC is more likely to cause adverse bioeffects than...
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