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Quinazoline-2,4( $$1H,3H$$ )-diones exhibit a wealth of biological activities including antitumor proliferation. We established an improved method for the synthesis of quinazoline-2,4( $$1H,3H$$ )-dione derivatives with three points of molecular diversity. Data indicate that compounds 60 (average $$\text{ logGI}_{50} \!=\! -6.1$$ ), 65 (average $$\text{ logGI}_{50} \!=\! -6.13$$ ), 69...
Both sulfonopeptides and phosphonopeptides are important analogs of naturally occurring peptides and have been widely used as enzyme inhibitors and haptens for producing catalytic antibodies due to their tetrahedrally structural features. A series of hybrid sulfonophosphinodipeptides composing of taurines and 1-aminoalkylphosphinic acids were first and conveniently synthesized in satisfactory to good...
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