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Goal: Whole-exome sequencing provides a more cost-effective way than whole-genome sequencing for detecting genetic variants, such as copy number variations (CNVs). Although a number of approaches have been proposed to detect CNVs from whole-genome sequencing, a direct adoption of these approaches to whole-exome sequencing will often fail because exons are separately located along a genome. Therefore,...
Recently, more evidence of polygenicity and pleiotropy has been found in genome-wide association (GWA) studies of complex psychiatric diseases (e.g., schizophrenia), where multiple interacting genetic variants may affect multiple phenotypic traits simultaneously. In this work, we propose a new sparse collaborative group-ridge low-rank regression model (sCGRLR) to study the pleiotropic effects of a...
Exome sequencing provides us an effective way to discover genetic factors that might be associated with phenotypes for complex diseases. Compared with the whole-genome sequencing, exome sequencing can satisfy the high sequencing coverage requirement while under the limited budge constraint. However, due to the nature that exons are distributed sparsely along the genome, and the technical variability...
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