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Die unkonventionelle Terpensynthase Iridoid‐Synthase (IRIS) produziert Nepetalactol, eine Vorstufe für Wirkstoffe wie Vincristin. In ihrer Zuschrift auf S. 15698 ff. präsentieren E. Oldfield, R.‐T. Guo et al. die Strukturen von IRIS aus Cantharanthus roseus im Komplex mit NADP und dem Substrat 10‐Oxogeranial. Die Strukturen zeigen, wie Nepetalactol und das Beiprodukt Oxo‐Citronellal gebildet werden,...
Structures of the iridoid synthase nepetalactol synthase in the presence of NAD+, NADPH or NAD+/10‐oxogeranial were solved. The 10‐oxogeranial substrate binds in a transoid‐O1‐C3 conformation and can be reduced by hydride addition to form the byproduct S‐10‐oxo‐citronellal. Tyr178 Oζ is positioned 2.5 Å from the substrate O1 and provides the second proton required for reaction. Nepetalactol product...
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