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The use of on-chip cellular activity monitoring for biological/chemical sensing is promising for environmental, medical and pharmaceutical applications. The miniaturization revolution in microelectronics is harnessed to provide on-chip detection of cellular activity, opening new horizons for miniature, fast, low cost and portable screening and monitoring devices. In this chapter we survey different...
A whole-cell bioluminescent biosensor dynamics based on genetically engineered Escherichia coli bacteria carrying a promoter-reporter fusion is often determined by a series of chemical reactions such as gene expression and reactions involving protein concentrations at nanomolar volume. In this paper, we derive an anayltical model of a whole-cell bioluminescent biosensor based on the Michaelis-Menten...
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