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Protein–protein interactions (PPIs) of 14‐3‐3 proteins are a model system for studying PPI stabilization. The complex natural product Fusicoccin A stabilizes many 14‐3‐3 PPIs but is not amenable for use in SAR studies, motivating the search for more drug‐like chemical matter. However, drug‐like 14‐3‐3 PPI stabilizers enabling such studies have remained elusive. An X‐ray crystal structure of a PPI...
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