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Dietary restriction (DR) reduced the metabolic activation of aflatoxin Bl) (AFB 1 ) in rats. This reduction may be attributed to the decrease of cytochrome P-450-mediated AFB 1 epoxidation and/or increase in the detoxification of AFB 1 catalyzed by hepatic glutathione S-transferase (GST) and other phase II detoxification enzymes. In this study the effect of DR on male rat...
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