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D‐Amino acid oxidase (DAO) catalyzes oxidative deamination of D‐amino acids. Since D‐amino acids are considered to be rare in eukaryotes, physiological function of this enzyme has been enigmatic for a long time. Mutant mice lacking DAO were found, and their strain was established. The urine of the mutant mice contained large amounts of D‐amino acids. D‐Amino acids were also present in their organs...
Serine racemase (SRR) is a brain-enriched enzyme that converts l-serine to d-serine, which acts as an endogenous ligand of N-methyl d-aspartate (NMDA) receptors. Dysfunction of SRR may reduce the function of NMDA receptors and susceptibility to schizophrenia.We genotyped three single-nucleotide polymorphisms (SNPs) of the 5′ region of the SRR gene in 525 patients with schizophrenia and 524 healthy...
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