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Collagen is the most abundant organic component of bone. It constitutes a superfamily of extracellular matrix proteins whose primary function is structural. The major collagenous component of bone is type I collagen, but types III, V, and X collagens are also found in bone tissue. Recently it was reported that collagen is essential for the growth and differentiation of various kinds of cell including...
Collagen has been reported to be essential for the proliferation of various kinds of cells including human osteoblastic cells [Takamizawa, S., Maehata, Y., Imai, K., Senoo, H., Sato, S., Hata, R., 2004. Effects of ascorbic acid and ascorbic acid 2-phosphate, a long-acting vitamin C derivative, on the proliferation and differentiation of human osteoblast-like cells. Cell Biol. Int. 28, 255–265], but...
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