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We report a Japanese autopsy case of progressive supranuclear palsy (PSP). The male patient was 74years old at the time of death. At age 64, he developed non-fluent aphasia that progressed slowly over 8years, eventually associated with behavioral abnormality, postural instability, and dysphagia at 2years prior to his death. Magnetic resonance imaging of the brain at age 73 demonstrated marked atrophy...
Abstract We examined the apolipoprotein E (ApoE) genotypes of 19 middle-aged non-demented subjects with cerebral amyloid protein (A) deposits, and compared the results with those of 16 patients with sporadic Alzheimers disease (AD) and those of 34 age-matched controls. The frequency of the ApoE 4 allele was higher (P = 0.0256) in these 19 subjects (0.211) than in controls (0.059), and was close to...
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