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In this letter we report a method for the preparation of optically active 4-hydroxy-Δ 2 -isoxazolines. This methodology relies on the use of a camphorsultam substituted vinylboronic ester which upon nitrile oxide cycloaddition and oxidation affords the optically active 4-hydroxy-Δ 2 -isoxazolines in good yield.
In this letter we report a general method for the preparation of optically active 4-hydroxy-Δ 2 -isoxazolines. This one-pot method employs sodium percarbonate for nitrile oxide generation, oxidation of the intermediate boronic ester substituted Δ 2 -isoxazoline, and cleavage of the chiral auxiliary from the final product.