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Summary A sensitive HPLC method with fluorescence detection is described for the analysis of lomefloxacin (LOM) in biological samples; sarafloxacin (SAR) is used as internal standard. Sample preparation was performed by adding phosphate buffer (pH 7.4, 0.1m) then extraction with trichloromethane. LOM and the internal standard were separated by HPLC on a reversed-phase column with aqueous phosphate...
The cytotoxicity of 10 chemicals from the Multicentre Evaluation of In vitro Cytotoxicity (MEIC) list (nos 21-30) was evaluated in human and rat cultured hepatocytes and in two established cell lines (HepG2 and 3T3) according to the MEIC programme organized by the Scandinavian Society of Cell Toxicology. The MTT test was used as the endpoint of cytotoxicity after 24 hr of exposure to the chemicals...
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