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We simulate the pathophysiology of severe burn trauma and burn-induced sepsis, using rat models of experimental burn injury and cecal ligation and puncture (CLP) either individually (singe-hit model) or in combination (double-hit model). The experimental burn injury simulates a systemic but sterile pro-inflammatory response, while the CLP simulates the effect of polymicrobial sepsis. Given the liver׳s...
Burn injuries together with its subsequent complications, mainly bacterial infections originating from gastrointestinal tract, activate the host immune system through stimulation of a series of local and systemic responses, including the release of inflammatory mediators. To gain a more comprehensive understanding of these complex physiological changes and to propose therapeutic approaches to combat...
Due to the inherent complexities involved in understanding a redundant, non-linear process like inflammation, systems biology modeling approaches have been proposed. While these models have produced encouraging results, they do not take into account the circadian nature of many of their components. Circadian rhythms are daily variations in a wide number of biological processes, including many of the...
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