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We have extended our previous yeast two-hybrid findings to show that 14-3-3β also interacts with the insulin-like growth factor I receptor (IGFIR) in mammalian cells overexpressing both proteins and that the interaction involves serine 1283 and is dependent on receptor activation. Treatment of cells with the phorbol ester PMA stimulates the interaction of 14-3-3β with the IGFIR in the absence of receptor...
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