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Vascular endothelial growth factor (VEGF) can overcome a potential anti-angiogenic effect of TNF-α by inhibiting endothelial apoptosis induced by this cytokine. Soluble TNF-α receptor I (sTNFRI) is an extracellular domain of TNFRI and antagonizes the activity of TNF-α. Here we report that sTNFRI is able to stimulate the growth of endothelial cells not by antagonizing TNF-α. Exogenously added recombinant...
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