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MicroRNAs are small endogenous noncoding RNAs, which modulate target gene expression by binding with target mRNA sequences in the 3′untranslated region (UTR) with an imperfect complementarity that inhibits the mRNA translation. Many microRNAs have been reported to function as tumor oncogenes or anti-oncogenes. Recently, more and more microRNAs have been reported to contribute to a tumor's invasive...
Piwi, highly conserved during evolution, has been reported to play a key role in stem cell self-renewal in several different organisms. As one of the four human homologues of the Piwi family, Hiwi has been demonstrated to be significantly overexpressed in some human cancer. However, the relationship between Hiwi and human gliomas is unclear. In this study, we investigated the clinical significance...
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