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The complex pathogenesis of Alzheimer's disease (AD) calls for multi‐target approach for disease treatment. Herein, based on the MTDLs strategy, a series of phthalimide‐(N‐alkylbenzylamine) cysteamide hybrids were designed, synthesized, and investigated in vitro for the purpose. Most of the target compounds were found to be potential multi‐target agents. In vitro results showed that compound 9e was...